Abstract #3023

Measuring and minimizing effects of eddy currents on selective spectral editing experiments at 3T

Georg Oeltzschner^1,2, Karim Snoussi^1,2, Nicolaas A.J. Puts^1,2, Mark Mikkelsen^1,2, Ashley D. Harris^3,4,5, Subechhya Pradhan^6,7, Kyrana Tsapkini⁸, Michael Schär¹, Peter B. Barker^1,2, and Richard A.E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³CAIR Program, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁴Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁵Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Calgary, AB, Canada, ⁶Diagnostic Imaging and Radiology, Children’s National Health System, Washington, DC, United States, ⁷Department of Radiology, George Washington University, Washington, DC, United States, ⁸Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Macromolecule-suppressed J-difference-edited MRS of GABA is extremely sensitive to B₀ offsets. Relatively small frequency shifts (~10 Hz) may cause unwanted co-editing of macromolecules, to the extent that the edited ‘GABA’ signal appears negative in-vivo. We demonstrate an approach to measure transient field shifts arising from gradient-related eddy currents, and present a way to minimize these effects in order to restore correct editing.

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