Abstract #3024

MEGA-PRIAM: Dual-volume excitation and parallel reconstruction for J-difference-edited MR spectroscopy

Georg Oeltzschner^1,2, Nicolaas A.J. Puts^1,2, Kimberly L. Chan^1,2,3, Vincent O. Boer⁴, Peter B. Barker^1,2, and Richard A.E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Hvidovre Hospital, Danish Research Center for Magnetic Resonance, Hvidovre, Denmark

A twofold acceleration of MEGA-edited spectroscopy, using Parallel Reconstruction In Accelerated Multivoxel (MEGA-PRIAM) to simultaneously acquire data in two separate locations, is demonstrated. PRIAM separates the signals from two dualband-excited voxels using spatial receiver-coil sensitivity profiles. Phantom experiments show that MEGA-PRIAM separates GABA- and glutathione-edited spectra with low crosstalk between the voxels. In-vivo experiments establish that dual-voxel MEGA-PRIAM increases signal-to-noise ratio (SNR) 40% compared to sequentially acquired single-voxel MEGA-PRESS measurements with the same total duration. GABA and glutathione estimates are consistent between dual-voxel MEGA-PRIAM and single-voxel MEGA-PRESS acquisitions.

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