Abstract #3025

Quantifying pO2-Driven Longitudinal Relaxation of Water 1H Spins in the Presence of Magnetization Transfer: Cross-Linked BSA as a Tissue Mimic

Kelsey Meinerz¹, Tianzhe Li², Scott C. Beeman³, Joel R. Garbow^3,4, and Joseph J.H. Ackerman^2,3,4

¹Physics, Washington University, Saint Louis, MO, United States, ²Chemistry, Washington University, Saint Louis, MO, United States, ³Radiology, Washington University, Saint Louis, MO, United States, ⁴Siteman Cancer Center, Washington University, St Louis, MO, United States

Crosslinked bovine serum albumin phantoms are used as tissue biexponential relaxation surrogates/mimics to investigate the potential of R₁-based tissue-O₂ quantification and to characterize the influence of physiologically relevant variations of temperature and protein concentration on such determinations. The relaxation-rate constant for the rapidly relaxing apparent water population is dominated by magnetization transfer and is insensitive pO₂. The relaxation-rate constant for the slowly relaxing apparent water population is linearly related to pO₂ and provides the basis for a possible MR-Oximetry protocol.

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