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Abstract #3026

Brain redox imaging using blood-brain-barrier nitroxides by digital EPR imaging system

Miho C Emoto1, Hideo Sato-Akaba2, and Hirotada G Fujii1

1Sapporo Medical University, Sapporo, Japan, 2Osaka University, Osaka, Japan

Electron paramagnetic resonance (EPR) imaging is a noninvasive imaging method for visualizing the brain redox status using nitroxide compounds as imaging probes. A digital imaging system for three-dimensional continuous-wave EPR imaging of small animals was developed using a high-speed analog-to-digital converter, digital-to-analog converters and field programmable gate array integrated circuits to improve the signal-to-noise ratio (SNR) and visualize the precise brain redox status in mice. Compared to an analog EPR imager, the digital EPR imager obtains a higher SNR of a phantom and produces images with sufficient quality to create a more accurate brain redox map of the mouse head.

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