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Abstract #3033

SQUID-based ultralow field nuclear magnetic resonance spectroscopy using the para-H2 based hyperpolarization technique SABRE

Kai Buckenmaier1, Matthias Rudolph1,2, Christoph Back2, Joern Engelmann1, Juri Rudin1, Tomasz Misztal3, Ute Bommerich4, Klaus Scheffler1, Dieter Koelle2, Reinhold Kleiner2, Hermann Mayer3, Johannes Bernarding4, and Markus Plaumann4

1High-field Magnetic Resonance, MPI for Biological Cybernetics, Tuebingen, Germany, 2Physikalisches Institut and Center for Quantum Science (CQ) in LISA+, University of Tübingen, Germany, 3Institue of Inorganic Chemistry, University of Tübingen, Germany, 4Department for Biometrics and Medical Informatics, Otto-von-Guericke-University Magdeburg, Germany

SABRE is a technique to achieve continuous hyperpolarization for MR measurements by the interaction of para-hydrogen and a substrate via steady ligand exchange on a catalyst. Thus, MR-active nuclei can be hyperpolarized more than only once. At field strengths of mT Faraday coils, commonly used in conventional or high field MRI, become insensitive and SQUIDs performing superior. Since SQUIDs are broadband detectors, the static magnetic field B0 can be changed easily or multiple nuclei can be measured simultaneously. Here, we successfully demonstrate the advantages of a SQUID based system by showing significant signal enhancement (1H, 19F) by hyperpolarization of 3-fluoropyridine.

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