Hyperpolarized 13C MRI leverages an over 10 000 times increase in the 13C polarization of biomolecules, enabling new molecular imaging applications. However, metabolic applications are limited to processes on the timescale of a minute by the short lifetime of the hyperpolarized signal. Here, we hyperpolarize nanodiamonds and microdiamonds to achieve large, long-lived 13C polarizations. We then image these particles in phantoms, demonstrating the potential of hyperpolarized nanodiamonds for imaging over long timescales. As nanodiamond has been established as a biocompatible platform for drug delivery, our results will motivate further research into hyperpolarized MRI for tracking nanoparticles in vivo.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords