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Abstract #3038

Examination of the hyperpolarizability of fluorinated nicotinic acids and further pyridine carboxylic acids using SABRE

Markus Plaumann1, Frederike Euchner1, Rainer Ringleb1, Sara Hadjiali2, Joachim Bargon3, Gerd Buntkowsky2, Johannes Bernarding1, and Ute Bommerich1

1Department for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, 2Eduard-Zintl-Institute for Inorganic and Physical Chemistry, Technical University Darmstadt, Darmstadt, Germany, 3Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany

Nicotinic acid and isonicotinic acid are two derivatives of pyridine carboxylic acids. Both substrates are of high interest in medical chemistry. In the current study seven fluorinated derivatives of these pyridine carboxylic acids were chosen for examination of the 1H and 19F hyperpolarizability using the SABRE technique. Influences of the position of the carboxylic group and fluorine as well as the catalyst system concerning the achievable signal enhancements were examined. Furthermore an H/D-exchange could be observed in some cases. The presented data gives important information for future MR imaging studies.

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