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Abstract #3039

Resolving spin-spin couplings in hyperpolarized in vivo metabolic 13C spectroscopy at low magnetic field following murine tail-vein injection

Aaron M. Coffey1, Matthew A. Feldman1, Roman V. Shchepin1, Milton L. Truong1, Wellington Pham1, and Eduard Y. Chekmenev1

1Radiology, Vanderbilt University Institute of Imaging Science, Nashville, TN, United States

We demonstrate murine whole-body MRS and the ability to resolve the 13C multiplet of hyperpolarized 1-13C-succinate-d2 in a biplanar magnet with B0 = 0.0487 T and inhomogeneity <13 ppm over 40 cm DSV. At low magnetic field strength no loss of SNR relative to high field for a well-designed radiofrequency coil occurs, but chemical shift dispersion is potentially insufficient to differentiate hyperpolarized metabolites and contrast agents. However, at sufficiently low field strength, magnetic susceptibility derived B0 field inhomogeneity in vivo becomes negligible. Consequently, direct spectroscopic resolution of spin-spin couplings or J-couplings, more commonly performed near zero field, becomes feasible.

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