Dynamic imaging of HP pyruvate shows tremendous promise for offering new insight into tumor metabolism with unprecedented sensitivity, specificity, and spatiotemporal resolution. Imaging constraints due to the finite, nonstationary, and non-renewable signal pool necessitate the use of complex imaging and reconstruction strategies, but current approaches to validation of complex HP MRI measurements are lacking and new methods are critically needed. In this work, we investigate a framework for external validation of quantitative HP MRI biomarkers of tumor metabolism using stable isotope tracer analysis (MS-SITA). We show good agreement between quantitative biomarkers of chemical conversion derived from HP MRI and MS-SITA.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords