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Abstract #3049

Gd complex of DO3A-benzothiazole conjugate for neutron capture therapy

Ki-Hye Jung1, Ji-Ae Park1, Jung Young Kim1, Yongmin Chang2,3, Tae-Jeong Kim4, Hee-Kyung Kim4, Kyo Chul Lee1, Joo Hyun Kang1, and Yong Jin Lee1

1Division of RI-Convergence Research, Korea Institute of Radiological & Medical Sciences, Seoul, Korea, Republic of, 2Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, 3Department of Radiology and Molecular Medicine, Kyungpook National University, Daegu, Korea, Republic of, 4Institute of Biomedical Engineering Research, Kyungpook National University, Daegu, Korea, Republic of

We have presented a strategy for incorporating low-molecular-weight Gd(III) chelate for dual non-invasive MR contrast agent and NCT, without the necessity of loading individual contrast therapeutic drugs, which is usually required in theranostics. The Gd-DO3A-BTA injected and neutron irradiated group, the tumor growth was significantly suppressed. This information could provide a basis for the prospect of obtaining a synergistic or cumulative action of chemotherapy (ChT) and Gd-NCT. We examined the neutron capture irradiation of MDA-MB-231 mice in the presence of Gd-DO3A-BTA. The results indicate that Gd-DO3A-BTA is suitable neutron capture agent for Gd-NCT.

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