Abstract #3050

Mn-complex of DO2A-benzothiazole chelate as a new hepatobiliary MRI contrast agent

Soyeon Kim¹, Hee-Kyung Kim², Eun-Young Jeon³, Md. Kamrul Islam¹, Garam Choi¹, Au Reum Baek¹, Bo Kyung Sung¹, Tae-Jeong Kim³, and Yongmin Chang^1,2,4

¹Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, ²Department of Molecular Medicine & BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea, Republic of, ³Institute of Biomedical Engineering Research, Kyungpook National University, Daegu, Korea, Republic of, ⁴Department of Radiology, Kyungpook National University

The purpose of the present work is to design and synthesize a new bifunctional complex for use in Mn(II)-based liver-targeting MR imaging. Its r₁ relaxivity in human serum albumin (HSA) solution is 3.21 mM^-1s^-1, similar to MRI CA such as MnDPDP®. In vivo MR image after injection of Mn-DO2A-BTA by tail vein showed that its excretion is made via kidney and also bile duct, confirming hepatobiliary uptake.

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