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Abstract #3051

Cyclodextrin-based pseudo-rotaxanes as conjugatable molecular imaging biosensors for hyperpolarized 129Xe MRI

Braedan RJ Prete1, Simrun Chahal2, Ashvin Fernando3, Tao Li1, Francis Hane4, Brenton DeBoef3, and Mitchell Albert1

1Lakehead University, Thunder Bay, ON, Canada, 2University of Guelph, 3University of Rhode Island, 4Lakehead University, MURILLO, ON, Canada

Hyperpolarized (HP) 129Xe molecular imaging technology has recently advanced in the detection of biochemically inactive supramolecular cage-molecules within a living mammalian model. Unfortunately, the natural bio-distribution of these biosensor molecules is non-specific, which makes it difficult to precisely localize them in vivo using HP 129Xe MRI. With the HyperCEST detection of easily conjugated cyclodextrin-based pseudo-rotaxanes, we have identified a critical advancement in 129Xe biosensor design by uncovering a novel biosensor, which has the potential to precisely detect markers of early disease in a human body with comparable sensitivity to PET but with the spatial resolution of MRI.

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