Hyperpolarized (HP) 129Xe molecular imaging technology has recently advanced in the detection of biochemically inactive supramolecular cage-molecules within a living mammalian model. Unfortunately, the natural bio-distribution of these biosensor molecules is non-specific, which makes it difficult to precisely localize them in vivo using HP 129Xe MRI. With the HyperCEST detection of easily conjugated cyclodextrin-based pseudo-rotaxanes, we have identified a critical advancement in 129Xe biosensor design by uncovering a novel biosensor, which has the potential to precisely detect markers of early disease in a human body with comparable sensitivity to PET but with the spatial resolution of MRI.
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