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Abstract #3058

Extrinsic MRI contrast agents based on nuclear quadrupole enhanced relaxation: Principle, requirements and characterization of promising compounds

Christian Gösweiner1, Danuta Kruk2, Per-Olof Westlund3, Fischer Roland4, Schlögl Martin4, Markus Bödenler1, Andreas Petrovic1, Hermann Scharfetter1, and Stefan Spirk5

1Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 2Faculty of Mathematics and Computer Science, University of Warmia and Mazury in Olsztyn, Poland, 3Department of Chemistry, Umeå universitet, Sweden, 4Institute of Inorganic Chemistry, Graz University of Technology, Graz, Austria, 5Institute for Chemistry and Technology of Materials, Graz University of Technology, Graz, Austria

Quadrupole Relaxation Enhancement is a quantum mechanical effect that can be exploited to create a new generation of extrinsic contrast agents for usage in MRI. In this work we have investigated the physical requirements of such contrast agents have to meet to be useful. Based on our findings concerning nuclear quadrupole resonance-properties, spin relaxation behavior and toxicity we suggest a variety of 209Bi-aryl compounds. The sensitivity of these compounds onto chemical or magnetic field changes equip them with smart properties such as on/off switching of the contrast or molecular imaging.

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