Abstract #3059

Synthesis of Amplifiable Probe Gd-5-HT-DOTAGA and Application to Molecular Imaging of Pulmonary Inflammation

Aurora Rodriguez-Rodriguez¹, Nicholas Rotile¹, Julian Goding², Clemens K Probst³, Andrew M Tager³, Alexei Bogdanov, Jr², and Peter Caravan¹

¹A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²University of Massachusetts Medical School, Worcester, MA, United States, ³Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States

We report the synthesis of a new amplifiable MR probe that combines the stability of the macrocyclic Gd-DOTA core with the myeloperoxidase-reactive 5-hydroxytryptamide (5-HT) moiety. The relaxivity of Gd-5-HT-DOTAGA is increased 60% in the presence of myeloperoxidase activity. In a mouse model of bleomycin induced lung injury, the change in lung-to-muscle contrast to noise ratio is increased 50% compared to naïve animals, consistent with 3-fold higher Gd lung concentrations measured ex vivo.

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