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Abstract #3059

Synthesis of Amplifiable Probe Gd-5-HT-DOTAGA and Application to Molecular Imaging of Pulmonary Inflammation

Aurora Rodriguez-Rodriguez1, Nicholas Rotile1, Julian Goding2, Clemens K Probst3, Andrew M Tager3, Alexei Bogdanov, Jr2, and Peter Caravan1

1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2University of Massachusetts Medical School, Worcester, MA, United States, 3Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States

We report the synthesis of a new amplifiable MR probe that combines the stability of the macrocyclic Gd-DOTA core with the myeloperoxidase-reactive 5-hydroxytryptamide (5-HT) moiety. The relaxivity of Gd-5-HT-DOTAGA is increased 60% in the presence of myeloperoxidase activity. In a mouse model of bleomycin induced lung injury, the change in lung-to-muscle contrast to noise ratio is increased 50% compared to naïve animals, consistent with 3-fold higher Gd lung concentrations measured ex vivo.

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