Abstract #3060

Synthesis of hepatocyte-specific manganese complex with high kinetic stability and MR contrast characteristic for liver cancer imaging

Heekyung Kim¹, Garam Choi², Md. Kamrul Islam², Soyeon Kim², Ah Rum Baek², Bo Kyung Sung², Eunyoung Jeon³, Tae-Jeong Kim³, and Yongmin Chang^1,2,4

¹BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea, Republic of, ²Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, ³Institute of Biomedical Engineering Research, Kyungpook National University, ⁴Radiology, Kyungpook National University

Novel manganese (II) complex based on EDTA coordination cage bearing benzothiazole aniline (BTA) moiety with high chelation stability was designed and synthesized for use as a liver-specific MRI contrast agent. In addition to forming a hydrophilic, this new hepatobiliary Mn(II) chelate is rapidly taken up by hepatocyte of liver. The magnetic and kinetic properties of Mn(II) complex are higher than commercially available analogue, Mn-DPDP, which was clinically approved MR liver contrast agent. The complex, Mn-EDTA-BTA, was evaluated via in vivo MR imaging to prove high tumor detection sensitivity using animal liver tumor model.

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