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Abstract #3060

Synthesis of hepatocyte-specific manganese complex with high kinetic stability and MR contrast characteristic for liver cancer imaging

Heekyung Kim1, Garam Choi2, Md. Kamrul Islam2, Soyeon Kim2, Ah Rum Baek2, Bo Kyung Sung2, Eunyoung Jeon3, Tae-Jeong Kim3, and Yongmin Chang1,2,4

1BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea, Republic of, 2Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, 3Institute of Biomedical Engineering Research, Kyungpook National University, 4Radiology, Kyungpook National University

Novel manganese (II) complex based on EDTA coordination cage bearing benzothiazole aniline (BTA) moiety with high chelation stability was designed and synthesized for use as a liver-specific MRI contrast agent. In addition to forming a hydrophilic, this new hepatobiliary Mn(II) chelate is rapidly taken up by hepatocyte of liver. The magnetic and kinetic properties of Mn(II) complex are higher than commercially available analogue, Mn-DPDP, which was clinically approved MR liver contrast agent. The complex, Mn-EDTA-BTA, was evaluated via in vivo MR imaging to prove high tumor detection sensitivity using animal liver tumor model.

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