Abstract #3064

A novel tracer for non-invasive atherosclerotic plaque phenotyping by PET/MR imaging

Max L Senders^1,2, Calvin Yeang³, Hannah Groenen¹, Francois Fay¹, Claudia Calcagno¹, Simone Green³, Phuong Miu³, Thomas Reiner⁴, Joseph L Witztum³, Zahi A Fayad¹, Willem J M Mulder¹, Carlos Perez-Medina¹, and Sotirios Tsimikas³

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Medical Biochemistry, Academic Medical Center, Amsterdam, Netherlands, ³Division of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California, La Jolla, San Diego, CA, USA., ⁴Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Atherosclerotic plaques that rupture can cause stroke or myocardial infarction. Oxidation specific epitopes (OSE), as present in oxidized LDL (OxLDL), are hallmarks of vulnerable plaques . We have developed the PET radiotracer ⁸⁹Zr-LA25 that targets OSE. Integration of ⁸⁹Zr-LA25 PET imaging with previous validated techniques enables  ‘’vulnerable’’ plaque phenotyping by PET/MRI

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