Abstract #3065

A new highly stable macrocyclic gadolinium complex as a liver targeting MRI contrast agent

Heekyung Kim¹, Ah Rum Baek², Soyeon Kim², Eun-Young Jeon³, MD. Kamrul Islam², Garam Choi², Bo Kyung Sung², Tae-Jeong Kim³, and Yongmin Chang^1,2,3,4

¹BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea, Republic of, ²Medical &Biological Engineering, Kyungpook National University, ³Biomedical Engineering Research Instite, Kyungpook National University, ⁴Radiology, Kyungpook National University

Gd-EOB-DO3A is prepared according to the general synthetic methods, and characterized by spectroscopic analysis. The relaxivities are r1 = 8.07, r2 = 8.57 mM-1s-1. From in vivo T1-weighted MR images, we observe good liver-specific enhancement that can be compared with commercial liver targeting agents, and confirm the biliary excretion via gallbladder. Also the kinetic stability of the gadolinium complex was determined with time-dependent longitudinal relaxation rate (R1,p(t)/R1,p(0)) and the relaxation was maintained above 70% against to initial value during the measurement.

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