Meeting Banner
Abstract #3065

A new highly stable macrocyclic gadolinium complex as a liver targeting MRI contrast agent

Heekyung Kim1, Ah Rum Baek2, Soyeon Kim2, Eun-Young Jeon3, MD. Kamrul Islam2, Garam Choi2, Bo Kyung Sung2, Tae-Jeong Kim3, and Yongmin Chang1,2,3,4

1BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea, Republic of, 2Medical &Biological Engineering, Kyungpook National University, 3Biomedical Engineering Research Instite, Kyungpook National University, 4Radiology, Kyungpook National University

Gd-EOB-DO3A is prepared according to the general synthetic methods, and characterized by spectroscopic analysis. The relaxivities are r1 = 8.07, r2 = 8.57 mM-1s-1. From in vivo T1-weighted MR images, we observe good liver-specific enhancement that can be compared with commercial liver targeting agents, and confirm the biliary excretion via gallbladder. Also the kinetic stability of the gadolinium complex was determined with time-dependent longitudinal relaxation rate (R1,p(t)/R1,p(0)) and the relaxation was maintained above 70% against to initial value during the measurement.

This abstract and the presentation materials are available to members only; a login is required.

Join Here