Abstract #3066

Highly Sensitive Magnetic Nanoprobe for Detection of ErbB2-expressing Cancer

Dan Heo^1,2, Jaemoon Yang¹, and Jin-Suck Suh¹

¹Department of Radiology, Yonsei University College of Medicine, Seoul, Korea, Republic of, ²Nanomedical National Core Research Center, Yonsei University, Seoul, Korea, Republic of

ErbB2, which belongs to the epidermal growth factor receptor (EGFR) family, plays a key role in human malignancies. ErbB2 is overexpressed in approximately 30% of human breast cancers and in many other cancer types, including stomach, bladder, ovarian and lung carcinomas. The objective of this study is the development of anti-ErbB2 aptamer-modified T2 contrast agent based on magnetic nanoprobe (Apt_ErbB2-MNP) having high-specificity onto Erbb2-expressing cancer. For confirmation of Apt_ErbB2-MNP as T2 contrast agent, T2 relaxivity and hydrodynamic diameter was measured. in vitro binding affinity tests were conducted not only recombinant ErbB2 proteins but also the live cells. in vivo targeting ability was verified by in vivo MRI analysis.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.