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Abstract #3068

In vitro and in vivo detection of treatment-induced apoptosis using ultrasmall superparamagnetic iron oxide (USPIO)-conjugated Annexin V: A pilot study

Osamu Togao1, Akihiro Nishie1, Chihiro Tamura2, Mayumi Yamato2, Kazuhiro Ichikawa2, Satoshi Nohara3, Yoshio Ito3, Naoki Kato4, Satoshi Yoshise4, and Hiroshi Honda1

1Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Innovation Center for Medical Redox Navigation, Kyushu University, 3Meito Sangyo Co., LTD, 4Guerbet Japan KK

Apoptosis is involved in many pathological processes. Early detection of treatment-induced apoptosis in malignant tumors is clinically useful for a decision making in therapeutic strategy. Phosphatidylserine (PS) expressed on the cell membrane is known to be a marker of apoptosis which can be detected by probes with Annexin V. In this study, we newly synthesized USPIO-conjugated Annexin V and investigated its potential in the use in apoptosis imaging in both in vitro and in vivo studies.

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