Abstract #3068

In vitro and in vivo detection of treatment-induced apoptosis using ultrasmall superparamagnetic iron oxide (USPIO)-conjugated Annexin V: A pilot study

Osamu Togao¹, Akihiro Nishie¹, Chihiro Tamura², Mayumi Yamato², Kazuhiro Ichikawa², Satoshi Nohara³, Yoshio Ito³, Naoki Kato⁴, Satoshi Yoshise⁴, and Hiroshi Honda¹

¹Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Innovation Center for Medical Redox Navigation, Kyushu University, ³Meito Sangyo Co., LTD, ⁴Guerbet Japan KK

Apoptosis is involved in many pathological processes. Early detection of treatment-induced apoptosis in malignant tumors is clinically useful for a decision making in therapeutic strategy. Phosphatidylserine (PS) expressed on the cell membrane is known to be a marker of apoptosis which can be detected by probes with Annexin V. In this study, we newly synthesized USPIO-conjugated Annexin V and investigated its potential in the use in apoptosis imaging in both in vitro and in vivo studies.

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