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Abstract #3069

A Bright Contrast Labelling Approach for Non-Invasive MR Imaging of Biomaterials

Daniel Andrzej Szulc1,2, Tameshwar Ganesh2,3, Maryam Abdinejad4, Hanlin Liu4,5, Xiao-an Zhang4,5, and Hai-Ling Margaret Cheng1,2,6

1Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada, 2Ted Rogers Centre for Heart Research, Translational Biology & Engineering Program, Toronto, ON, Canada, 3Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada, 4Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, ON, Canada, 5Department of Chemistry, University of Toronto, Toronto, ON, Canada, 6Edward S. Rogers Sr. Department of Electrical & Computer Engineering, University of Toronto, Toronto, ON, Canada

Tissue engineered biomaterials have the potential to regenerate almost every tissue type. One difficult aspect to advancing this technology is determining the properties and fate of these materials once introduced in vivo. Non-invasive imaging technology such as MRI holds significant potential for monitoring implanted biomaterials. Few novel approaches to directly image biomaterials have recently been developed; however, most are designed for specific materials or utilize iron oxides with limited specificity. In this study, we investigate a novel approach to labelling biomaterials with a highly efficient T1 agent and a biologically derived adhesive, which allows for accurate and sensitive detection in vivo.

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