Meeting Banner
Abstract #3073

Improved tracking and quantification of SPIO-labeled cells using bSSFP with compressed sensing TurboSPI

Zoe O'Brien-Moran1,2, Marie-Laurence Tremblay1, Christa Davis1, James Rioux1,2,3, and Kimberly Brewer1,2,3,4

1Biomedical Translational Imaging Centre (BIOTIC), Halifax, NS, Canada, 2Physics, Dalhousie University, Halifax, NS, Canada, 3Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, 4Microbiology, Dalhousie University, Halifax, NS, Canada

Understanding immune cell behaviour is important for evaluating therapeutic response in pre-clinical models. We monitor cell migration in a mouse model of cervical cancer by labeling cells with superparamagnetic iron oxide (SPIO). Simultaneous pre-clinical PET/MRI confirmed that the balanced steady-state free precession (bSSFP) sequence lacks specificity to SPIO-labeled cells within the tumor. We tested TurboSPI, a multi-echo single point imaging technique with compressed sensing that provides high temporal resolution 3D R2* mapping in under 45 minutes. These maps exhibit superior SPIO specificity compared to bSSFP images and enabled us to do both qualitative and quantitative cell tracking.

This abstract and the presentation materials are available to members only; a login is required.

Join Here