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Abstract #3076

­­Non-invasive imaging of macrophage accumulation in abdominal aortic aneurysm by 19F MRI

Sebastian Temme1, Guang Yang 2, Christoph Jacoby3, Stegbauer Johannes 2, and Flögel Ulrich 1

1Molecular Cardiology, University of Düsseldorf, Düsseldorf, Germany, 2Department of Internal Medicine/Nephrology, University Hospital Düsseldorf, Düsseldorf, Germany, 3Division of Cardiology, Pulmonology and Vascular Medicine, University of Düsseldorf, Düsseldorf, Germany

Abdominal aortic aneurysms (AAA) are a relatively common disease, with still unclear etiology that is associated with high mortality due to aortic rupture. Here we show that mice deficient for the Mas-receptor show aggravated AAA formation upon Ang-II treatment and that accumulation of macrophages in bulk aneurysms can be non-invasively visualized by 1H/19F MRI using intravenously applied perfluorocarbon nanoemulsions which are efficiently phagocytosed by macrophages. We conclude that Mas-receptor deficiency leads to increased inflammation with enhanced AAA formation and that 19F MRI-based inflammation imaging will help to further unravel the role of monocytes/macrophages in the course of AAA progression.

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