Abstract #3075

19F MR-Imaging of acute thrombi using a clinically relevant perfluorocarbon nanoemulsion

Sebastian Temme¹, Christoph Jacoby², Christoph Grapentin³, Jürgen Schrader¹, and Ulrich Flögel¹

¹Molecular Cardiology, University of Düsseldorf, Düsseldorf, Germany, ²Division of Cardiology, Pulmonology and Vascular Medicine, University of Düsseldorf, Düsseldorf, Germany, ³Pharmaceutical Technology and Biopharmacy, University of Freiburg, Freiburg i. Br.

Exact localization of acute thrombi is still a serious problem in the clinical setting. Here we show the feasibility of artefact-free ¹⁹F MR-imaging using clinically relevant PFOB-nanoemulsions functionalized with an α2-antiplasmin peptide, specific for early thrombi. Utilizing the isolated CF₃-peak of PFOB in combination with a conventional ¹⁹F RARE sequence is suitable for specific and artefact-free imaging of acute thrombi in vitro and also in vivo.

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