Meeting Banner
Abstract #3078

Detection of metastasis-associated macrophages in the lung, lymph nodes and brain using fluorine-19 based MRI cell tracking

Ashley V Makela1,2 and Paula J Foster1,2

1Medical Biophysics, Western University, London, ON, Canada, 2Robarts Research Institute, London, ON, Canada

The escape and invasion of cancer cells and the growth of metastatic tumors is in part due to the role of tumor associated macrophages. The macrophages present in these metastatic sites are called metastasis associated macrophages. This study used 19F-based cellular MRI to detect lymph node, lung and brain metastases arising from breast cancer. A custom built 1H/19F birdcage coil allowed for ‘head to toe’ mouse imaging, allowing for detection of 19F agent accumulation, with 1H images verifying anatomical location. This information may be useful in understanding the timing and role of macrophages in the metastatic process.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords