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Abstract #3078

Detection of metastasis-associated macrophages in the lung, lymph nodes and brain using fluorine-19 based MRI cell tracking

Ashley V Makela1,2 and Paula J Foster1,2

1Medical Biophysics, Western University, London, ON, Canada, 2Robarts Research Institute, London, ON, Canada

The escape and invasion of cancer cells and the growth of metastatic tumors is in part due to the role of tumor associated macrophages. The macrophages present in these metastatic sites are called metastasis associated macrophages. This study used 19F-based cellular MRI to detect lymph node, lung and brain metastases arising from breast cancer. A custom built 1H/19F birdcage coil allowed for ‘head to toe’ mouse imaging, allowing for detection of 19F agent accumulation, with 1H images verifying anatomical location. This information may be useful in understanding the timing and role of macrophages in the metastatic process.

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