2-hydroxyglutarate (2-HG) is an oncometabolite that accumulates in various cancers as a result of mutations in the isocitrate dehydrogenase (IDH1/2) genes and can be used as a biomarker for diagnosis. In this work, we demonstrate the fast conversion of glutamine to 2-HG and use it as a basis for developing a 2-HG in-vivo detection method. Using hyperpolarized [1-13C] glutamine and magnetic resonance imaging (MRI), we present the non-invasive unambiguous detection of 2-HG formation with high specificity from glutamine in-vivo and real-time in IDH1 and IDH2 mutant tumors.
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