Abstract #3080

Identifying Immune-Related Metabolic Properties of Pancreatic Cancer via Hyperpolarized Pyruvate Spectroscopic Imaging and NMR Metabolomics

Joseph Weygand^1,2, Prasanta Dutta¹, Jessica Molkentine³, Yeonju Lee^4,5, Travis Salzillo^1,2, Meifang Yu³, Jaehyuk Lee¹, Eugene Koay⁴, Cullen Taniguchi⁴, and Pratip Bhattacharya¹

¹Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, United States, ³Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁴Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁵Five Prime Therapeutics, Inc, San Francisco, CA, United States

Although immunotherapy presents an attractive new treatment option for patients with pancreatic cancer, its implementation has been underwhelming. As a critical first step in understanding this failure, we have applied hyperpolarized pyruvate spectroscopic imaging and NMR spectroscopy to interrogate the metabolic properties of pancreatic tumors cultivated in the presence of different immune environments. We observed that the immune environment in which a pancreatic tumor is harvested significantly alters metabolic function and that these metabolic differences exhibit a temporal dependence with respect to tumor development.

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