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Abstract #3085

Measuring perfusion in a renal ischemic/reperfusion rat model using hyperpolarized α-Trideuteromethyl[15N]glutamine.

Per Mose Nielsen1, Rolf F. Schulte2, Hayuin Qi1, and Christoffer Laustsen1

1MR Research Center, Aarhus University Hospital, Aarhus N, Denmark, 2GE Global Research, Munich, Germany

Renal IRI is a leading cause of AKI in several disease states; currently there are several methods to measure renal perfusion in the clinic, but all suffer under specific drawbacks. Here we present a pilot study using the hyperpolarized perfusion marker α-trideuteromethyl[15N]glutamine in a 40 min unilateral ischemia reperfusion rat model. A reduction of 51% in perfusion was observed in the animal. We therefore believe that α-trideuteromethyl[15N]glutamine is a highly promising molecule in renal perfusion studies.

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