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Abstract #3088

Influence of Isoflurane Anesthesia on Assessment of Cardiac Metabolism Using Hyperpolarized [1-13C] Pyruvate

Jonas Steinhauser1, Grzegorz Kwiatkowski 1, Patrick Wespi1, and Sebastian Kozerke1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

Isoflurane is frequently used in hyperpolarized [1-13C]pyruvate studies. Even though literature suggests direct interaction with mitochondrial metabolism, the influence of the compound on cardiac metabolism has not been assessed in detail yet. In the present study the impact of low versus high isoflurane concentration is examined in a cross-over experiment. Results reveal that cardiac metabolism is modulated by isoflurane concentration showing increased lactate and reduced bicarbonate production during high isoflurane dose relative to low dose.

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