Meeting Banner
Abstract #3089

Maternal-fetal exchange and metabolism followed in real-time by dynamic hyperpolarized 13C imaging on pregnant rats

Stefan Markovic1, Anne Fages1, Tangi Roussel2, Ron Hadas3, Michal Neeman3, and Lucio Frydman1

1Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2NeuroSpin Centre CEA Saclay, Gif-sur-Yvette, France, 3Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Monitoring placental metabolism is of particular interest for the early-detection of complications during pregnancy. This study discusses the use of dynamic nuclear polarization (DNP) enhanced 13C MRSI of hyperpolarized pyruvate, that has been injected into pregnant rats. The enzymatic conversion of pyruvate to lactate was followed in real-time in maternal and fetal compartments –including placentas. Lactate 13C signals in placentas could be observed; they peaked significantly later and were longer-lived than both placental 13C pyruvate and 13C signals in maternal organs. Single-voxel analyses for both metabolites in different organs revealed the T1 relaxation times and kinetics of the Pyr -> Lac transformation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here