Abstract #3089

Maternal-fetal exchange and metabolism followed in real-time by dynamic hyperpolarized 13C imaging on pregnant rats

Stefan Markovic¹, Anne Fages¹, Tangi Roussel², Ron Hadas³, Michal Neeman³, and Lucio Frydman¹

¹Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, ²NeuroSpin Centre CEA Saclay, Gif-sur-Yvette, France, ³Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

Monitoring placental metabolism is of particular interest for the early-detection of complications during pregnancy. This study discusses the use of dynamic nuclear polarization (DNP) enhanced ¹³C MRSI of hyperpolarized pyruvate, that has been injected into pregnant rats. The enzymatic conversion of pyruvate to lactate was followed in real-time in maternal and fetal compartments –including placentas. Lactate ¹³C signals in placentas could be observed; they peaked significantly later and were longer-lived than both placental ¹³C pyruvate and ¹³C signals in maternal organs. Single-voxel analyses for both metabolites in different organs revealed the T₁ relaxation times and kinetics of the Pyr -> Lac transformation.

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