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Abstract #3095

Reducing magnetization-transfer-induced T1 estimation error in myocardial T1 mapping for the MOLLI sequence: simulation, phantom and in vivo studies

Jiaxin Shao1, Dapeng Liu1, Kyung Hyun Sung1, Kim-Lien Nguyen2, and Peng Hu1

1Radiology, University of California, Los Angeles, CA, United States, 2Division of Cardiology, University of California, Los Angeles, CA, United States

The modified Look-Locker inversion-recovery (MOLLI) sequence is a widely used myocardial T1 mapping technique for tissue characterization. It is known that the MOLLI sequence underestimates myocardial T1 values (>10%) due to magnetization transfer (MT) effects and short myocardial tissue T2 values. In this work, we demonstrate that in vivo reduction of the inversion factor is predominantly responsible for the MT effect that reduces MOLLI T1 values. Thus, using an alternative T1 estimation algorithm with a measured inversion factor for the MOLLI sequence can reduce the MT effect on T1 estimation error.

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