Meeting Banner
Abstract #3094

Hyperpolarized [1-13C]-MRI in an ectothermic reptile

Kasper Hansen1,2, Per Mose Nielsen3, Esben Søvsø Szocska Hansen3,4, Cathrine Williams1, William Joyce1, Michael Pedersen2, Tobias Wang1, and Christoffer Laustsen3

1Section for Zoophysiology (Department of Bioscience), Aarhus University, Aarhus C, Denmark, 2Comparative Medicine Lab (Department of Clinical Medicine), Aarhus University, Aarhus N, Denmark, 3MR Research Centre (Department of Clinical Medicine), Aarhus University, Aarhus N, Denmark, 4Danish Diabetes Academy, Odense, Denmark

Many non-mammalian vertebrates hold enormous potential as “model animals” for various fields of basic physiological and biomedical research. Hyperpolarized magnetic resonance imaging (MRI) can provide quantitative in vivo information about metabolic processes including major pathways of the citric acid cycle and glycolysis via spectral differences of pyruvate intermediates. The combination of [1-13C]-MRI and model animals exhibiting “selected physiological traits” may be a strong tool for gaining novel insights into relevant metabolic mechanisms. In this pilot study we test, for the first time, the application of [1-13C]-MRI in an ectothermic reptile.

This abstract and the presentation materials are available to members only; a login is required.

Join Here