Abstract #3093

Enhancing metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-13C]pyruvate and dichloroacetate

Stephen J. DeVience¹, Xin Lu¹, Julie Proctor², Parisa Rangghran², Juliana Medina², Elias R. Melhem¹, Rao Gullapalli¹, Gary M. Fiskum², and Dirk Mayer¹

¹Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Anesthesiology and the Center for Shock, Trauma, and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD, United States

We investigated the use of dichloroacetate (DCA) in ¹³C-pyruvate imaging of traumatic brain injury as a way to improve bicarbonate signal strength and to elucidate changes in pyruvate dehydrogenase activity. Rats were injured with a controlled cortical impact and then injected with ¹³C-pyruvate before and after administration of DCA. Spectrally-resolved imaging was performed on the brain to quantify the resulting pyruvate, lactate, and bicarbonate signals. The bicarbonate signal and bicarbonate-to-lactate ratio were found to be sensitive to traumatic brain injury, and were affected equally by DCA in injured and uninjured hemispheres of the brain.

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