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Abstract #3093

Enhancing metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-13C]pyruvate and dichloroacetate

Stephen J. DeVience1, Xin Lu1, Julie Proctor2, Parisa Rangghran2, Juliana Medina2, Elias R. Melhem1, Rao Gullapalli1, Gary M. Fiskum2, and Dirk Mayer1

1Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Anesthesiology and the Center for Shock, Trauma, and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD, United States

We investigated the use of dichloroacetate (DCA) in 13C-pyruvate imaging of traumatic brain injury as a way to improve bicarbonate signal strength and to elucidate changes in pyruvate dehydrogenase activity. Rats were injured with a controlled cortical impact and then injected with 13C-pyruvate before and after administration of DCA. Spectrally-resolved imaging was performed on the brain to quantify the resulting pyruvate, lactate, and bicarbonate signals. The bicarbonate signal and bicarbonate-to-lactate ratio were found to be sensitive to traumatic brain injury, and were affected equally by DCA in injured and uninjured hemispheres of the brain.

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