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Abstract #3116

Dynamic Nitroxide-Enhanced MRI Detects Oxidative Stress in the Hearts of Mice Subject to Angiotensin II Infusion

Sophia Xinyuan Cui1, Rene J. Roy2, Brent A. French1,2, and Frederick H. Epstein1,2

1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Radiology, University of Virginia, Charlottesville, VA, United States

Oxidative stress contributes importantly to the pathophysiology of many types of cardiovascular disease. Nitroxides are relatively stable free radicals that have been used as redox-sensitive MRI contrast agents in preclinical studies to assess tumor redox status. We implemented a dynamic nitroxide-enhanced MRI method to test the hypothesis that MRI can detect cardiac oxidative stress in vivo. Imaging was performed in untreated controls and mice infused with angiotensin II for 7 days. The MRI signal decay rate in the heart was significantly higher in the angiotensin II group, indicating that these methods detect cardiac oxidative stress due to angiotensin II infusion.

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