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Abstract #3170

Free-breathing 3D Body Diffusion Imaging at 3T Using M1-compensated Diffusion Preparation and Stack-of-Stars Readout

Xiaoming Bi1, Christopher Nguyen2, Zhaoyang Fan2, Yutaka Natsuaki1, Rola Saouaf2, Debiao Li2, and Gerhard Laub1

1Siemens Healthcare, Los Angeles, CA, United States, 2Cedars-Sinai Medical Center, Los Angeles, CA, United States

Diffusion-weighted (DW) MRI enables qualitative and quantitative assessment of tissue diffusivity. Body diffusion imaging at 3T using conventional single-shot EPI sequence is challenged by respiratory and cardiac motions of subject, limited spatial resolution, and image distortion and ghosting. In this work, a new 3D imaging technique incorporating M1-compensated diffusion preparation and motion-robust stack-of-stars data acquisition was developed. Preliminary volunteer studies demonstrated its feasibility for free-breathing body diffusion imaging at 3T. From one patient underwent MR-PET scan, reduced ADC and increased FDG uptake was observed in the same focal lesion.

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