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Abstract #3173

Elucidation of Male Urethral Sphincter Complex Using Diffusion Tensor Imaging (DTI) based Fiber-Tracking

Kyoko Sakamoto1, Mahadevan Rajasekaran1, Valmiki Bhargava2, Vadim Malis3, and Shantanu Sinha4

1VA Medical Center, San Diego, CA, United States, 2VA Medical Center, 3Physics, UC San Diego, San Diego, CA, United States, 4Radiology, UC San Diego, San Diego, CA, United States

Urethral sphincters play an important role in urinary incontinence, a major clinical problem affecting the aging population. We elucidate the anatomy of the urethral sphincter muscles pertinent to urinary continence function using in vivo, non-invasive proton-density and diffusion tensor imaging and DTI-based fiber tracking in young adults. Muscle fiber tracking consistently revealed, perhaps for the first time, the existence of two sphincter like muscles, with one proximal near the bladder neck and the other more distal, supporting the two sphincter concept to constrict/close the urethral opening with important implications for the effect of prostatectomy on urethral closure function.

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