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Abstract #3180

Unbiased diffusional kurtosis measurements in the pelvis at low signal-to-noise ratio: A new approach for noise-level estimations

Olaf Dietrich1, Martina Brandlhuber1, Moritz J. Schneider1, Marco Armbruster1, Melvin D'Anastasi1, and Maximilian F. Reiser1

1Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany

The purpose of this study was to propose a robust technique for the determination of unbiased kurtosis values in body applications; for this aim, a new strategy to pixelwise estimate the noise level in DKI acquisitions is described and its feasibility for pelvic DKI is demonstrated in prostate tissue.

The "naive" evaluation (without considering the image noise) resulted in significantly biased positive kurtosis values of urine of $$$K=0.42\,($$$standard deviation: $$$0.06)$$$, indicating non-monoexponential signal decay caused by the influence of noise at higher b-values. This bias is almost completely removed ($$$K=-0.01\,(0.32)$$$) after including the pre-calculated noise-level map in the evaluation.

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