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Abstract #3181

Gradient First Moment Dependence of ADC in Liver Diffusion Weighting Imaging.

Kévin Moulin1, Eric Aliotta1,2, and Daniel B. Ennis1,2

1Department of Radiological Sciences, University of California, Los Angeles, CA, United States, 2Biomedical Physics IDP, University of California, Los Angeles, CA, United States

The effect of perfusion on Diffusion Weighting Imaging (DWI) and particularly the Apparent Diffusion Coefficient (ADC) at low b-value is a confounder in pathology assessment. In this study, in order to investigate the gradient first moment (M1) dependence of perfusion on the ADC, waveforms were generated using convex diffusion encoding (CODE) framework leading to a range of M1 for a given b-value. After comparing ADC calculated with different M1 and different b-value, we found that motion compensated waveform (M1=0) ensures independence of the ADC to perfusion even at low b-value, which can improve SNR.

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