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Abstract #3196

Accurate hepatic MRI proton density fat fraction assessment can be achieved with four regions-of-interest

Cheng William Hong1, Tanya Wolfson2, Ethan Z Sy1, Alexandra Schlein1, Soudabeh Fazeli Dehkordy1, Adrija Mamidipalli1, Scott B Reeder3, Rohit Loomba4, and Claude B Sirlin1

1Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Computational and Applied Statistics Laboratory, University of California, San Diego, San Diego, CA, United States, 3Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin, Madison, Madison, WI, United States, 4NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, CA, United States

A common approach to estimating a composite proton density fat fraction (PDFF) on MRI-PDFF maps is to draw a region-of-interest (ROI) in each of the nine Couinaud segments. This is laborious and technically challenging, however. In this secondary analysis of 398 patients, we demonstrate that 4-ROI sampling strategies that sample 2 ROIs in each hepatic lobe achieve close agreement with the 9-ROI composite. With further validation, a simple 4-ROI sampling strategy may become the new standard for measuring PDFF in clinical trials.

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