Abstract #3205

Assessment of magnetic resonance imaging markers in the event of drug induced liver toxicity

Abigail Kaur Chahil ¹, Dan Antoine ¹, Atul Minhas², Thomas Leather ², Anja Kipar³, Kevin Park¹, and Harish Poptani²

¹Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom, ²Centre for Pre-Clinical Imaging, University of Liverpool, Liverpool, United Kingdom, ³Institute for Veterinary Pathology, University of Zurich, Zurich, Switzerland

Challenges faced in diagnosis and treatment of drug induced liver injury (DILI) have formed the aim of this project to quantify non-invasive MRI and MRS markers to aide research into future therapeutics of DILI. Using an acetaminophen overdose model, we have managed to quantify 4 different MRI biomarkers: liver volume, T2 mapping, ADC and water/fat ratio. Significant changes were observed with an increase in liver volume and T2 relaxation and water/fat ratio, with a decrease in diffusion coefficient. Some degree of normalization in T2 and ADC values was noted after NAC treatment indicating that MRI and MRS can play an important role in the diagnosis of DILI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.