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Abstract #3205

Assessment of magnetic resonance imaging markers in the event of drug induced liver toxicity

Abigail Kaur Chahil 1, Dan Antoine 1, Atul Minhas2, Thomas Leather 2, Anja Kipar3, Kevin Park1, and Harish Poptani2

1Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom, 2Centre for Pre-Clinical Imaging, University of Liverpool, Liverpool, United Kingdom, 3Institute for Veterinary Pathology, University of Zurich, Zurich, Switzerland

Challenges faced in diagnosis and treatment of drug induced liver injury (DILI) have formed the aim of this project to quantify non-invasive MRI and MRS markers to aide research into future therapeutics of DILI. Using an acetaminophen overdose model, we have managed to quantify 4 different MRI biomarkers: liver volume, T2 mapping, ADC and water/fat ratio. Significant changes were observed with an increase in liver volume and T2 relaxation and water/fat ratio, with a decrease in diffusion coefficient. Some degree of normalization in T2 and ADC values was noted after NAC treatment indicating that MRI and MRS can play an important role in the diagnosis of DILI.

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