Abstract #3206

Quantitative characterization of disease progression in a mouse model of non-alcoholic steatohepatitis using molecular MR and non-contrast MR imaging

Philip Alan Waghorn¹, Diego Ferreira¹, Chloe Jones¹, Nicholas Rotile¹, Iris Chen¹, Chuantao Tu¹, Bryan Fuchs², and Peter Caravan¹

¹A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Division of Surgery, Massachusetts General Hospital, Boston, MA, United States

To deliver a non-invasive quantitative measure of patients with nonalcoholic fatty liver disease (NAFLD) who are likely to develop a fibrotic pathology, we characterized the natural history of a nonalcoholic steatohepatitis (NASH) mouse model using MRI. Characterization included fat quantification and MR relaxometry measurements by imaging at 4 time points and comparing with histology and biochemical markers. Fibrogenesis was assessed using the novel Gd-based MR probe, Gd-Hyd which was previously shown to detect fibrogenesis in a mouse CCl4 model of liver fibrosis

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