Abstract #3207

Using MRI to assess alterations in liver blood flow and oxygenation in response to physiological stress tests: meal challenge, hypercapnia and hyperoxia.

Eleanor F Cox^1,2, Naveenthan Palaniyappan², Richard Dury¹, Robert Scott², Guruprasad P Aithal², I Neil Guha², and Susan T Francis^1,2

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals Trust and the University of Nottingham, Nottingham, United Kingdom

Assessment of the capacity for dynamic changes in liver blood flow and oxygenation may provide a mechanism to improve the stratification of chronic liver injury. Here we assess dynamic hepatic blood flow and liver T₂* alterations in response to postprandial hyperaemia following a meal, and hypercapnia and hyperoxia gas challenges. We show significant changes in blood flow and T₂* in response to these challenges, and highlight that both the mode and FWHM of the T₂* distribution should be assessed. However, such stress tests can only be applied in participants with higher baseline T₂* for any change to be evident.

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