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Abstract #3207

Using MRI to assess alterations in liver blood flow and oxygenation in response to physiological stress tests: meal challenge, hypercapnia and hyperoxia.

Eleanor F Cox1,2, Naveenthan Palaniyappan2, Richard Dury1, Robert Scott2, Guruprasad P Aithal2, I Neil Guha2, and Susan T Francis1,2

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals Trust and the University of Nottingham, Nottingham, United Kingdom

Assessment of the capacity for dynamic changes in liver blood flow and oxygenation may provide a mechanism to improve the stratification of chronic liver injury. Here we assess dynamic hepatic blood flow and liver T2* alterations in response to postprandial hyperaemia following a meal, and hypercapnia and hyperoxia gas challenges. We show significant changes in blood flow and T2* in response to these challenges, and highlight that both the mode and FWHM of the T2* distribution should be assessed. However, such stress tests can only be applied in participants with higher baseline T2* for any change to be evident.

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