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Abstract #3241

Heart-Rate Independent T2 Mapping for Overcoming Loss of BOLD Sensitivity in Conventional Cardiac T2 MRI Acquired Under Vasodilator Stress

Hsin-Jung yang1, Damini Dey1, Jane Sykes2, John Butler2, Xiaoming Bi3, Behzad Sharif1, Ivan Cokic1, Sotirios Tsaftaris4, Debiao Li1, Piotr Slomka1, Frank Prato2, and Rohan Dharmakumar1

1Cedars Sinai Medical Center, Los Angeles, CA, United States, 2Lawson Health Research Institute, 3Siemens Healthcare, 4IMT School for Advanced Studies Lucca

Despite the advances to date, myocardial BOLD MRI continues to be plagued by imaging confounders, which limit its reliability. We hypothesized that (a) the loss in BOLD sensitivity is dependent on the magnitude of the change in heart rate (HR) between rest and vasodilator stress; and (b) HR-insensitive T2 maps can enable BOLD changes to be accurately captured. We tested our hypothesis by examining the BOLD response to a HR-insensitive T2 mapping approach and conventional T2 mapping. Our results show that reliability of T2-based myocardial BOLD MRI could be markedly improved through heart-rate-insensitive T2 acquisitions.

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