Abstract #3241

Heart-Rate Independent T2 Mapping for Overcoming Loss of BOLD Sensitivity in Conventional Cardiac T2 MRI Acquired Under Vasodilator Stress

Hsin-Jung yang¹, Damini Dey¹, Jane Sykes², John Butler², Xiaoming Bi³, Behzad Sharif¹, Ivan Cokic¹, Sotirios Tsaftaris⁴, Debiao Li¹, Piotr Slomka¹, Frank Prato², and Rohan Dharmakumar¹

¹Cedars Sinai Medical Center, Los Angeles, CA, United States, ²Lawson Health Research Institute, ³Siemens Healthcare, ⁴IMT School for Advanced Studies Lucca

Despite the advances to date, myocardial BOLD MRI continues to be plagued by imaging confounders, which limit its reliability. We hypothesized that (a) the loss in BOLD sensitivity is dependent on the magnitude of the change in heart rate (HR) between rest and vasodilator stress; and (b) HR-insensitive T2 maps can enable BOLD changes to be accurately captured. We tested our hypothesis by examining the BOLD response to a HR-insensitive T2 mapping approach and conventional T2 mapping. Our results show that reliability of T2-based myocardial BOLD MRI could be markedly improved through heart-rate-insensitive T2 acquisitions.

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