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Abstract #3250

Exenatide decreases ectopic fat accumulation but have no impact on myocardial function and perfusion in patients with obesity and type 2 diabetes

Ines Imane Abdesselam1, Anne Dutour2, Alexis Jacquier3, Frank Kober4, Patricia Ancel5, Oliver Rider6, Monique Bernard4, and Benedicte Gaborit2

1Aix-Marseille University, CRMBM, NORT, Marseille, France, 2Aix-Marseille University, NORT, AP-HM, 3Aix-Marseille University, CRMBM, AP-HM, 4Aix-Marseille University, CRMBM, 5Aix-Marseille University, NORT, 6University of Oxford, OCMR

The objective of the study is to assess the impact of Exenatide on endothelial reactivity, and change in ectopic fat and cardiac function. This study included 44 patients (mean 52 years) randomized to Exenatide or reference treatment. Magnetic resonance imaging was used to assess ectopic fat accumulation, coronary vasoreactivity and cardiac function. 16-weeks of Exenatide treatement resulted in a significant improvement in glycemic control and a significant reduction of both epicardial fat and hepatic steatosis. However, we found no effect of Exenatide on myocardial function. In addition, one-week of exenatide treatment had only a modest effect on vascular reactivity, albeit non-significant.

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