Abstract #3251

BOLD Effect of Oxygen-Inhalation T2-star MRI Surrogates Systemic and Myocardial Oxygen Consumption in Heart Failure and Myocardial Infarction

Michinobu Nagao¹, Kenji Fukushima¹, Umiko Ishizaki¹, Yuka Matsuo¹, Yuzo Yamasaki², Tetsuya Matoba³, Tomomi Ide³, Atsushi Takemura⁴, Mitsuru Momose¹, and Shuji Sakai¹

¹Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University, Tokyo, Japan, ²Clinical Radiology, Kyushu University, ³Cardiovascular Medicine, Kyushu University, ⁴Philips Electronics Japan

Measurement of oxygen consumption (OC) has been less than satisfactory in patients with heart failure. This has necessitated the invasive techniques to measure the total oxygen demand with cardiopulmonary exercise (CPX). The present study proposes a novel method to quantify OC using BOLD effect of oxygen-inhalation T2* MRI. Difference between oxygen-T2* and room-air-T2* (ΔT2*) was identified as an estimate of OC. ΔT2* was significantly correlated with systematic and myocardial OC expressed as the results of CPX and myocardial fatty acid scintigraphy. Our method allows assessing non-invasively OC in vivo. ΔT2* could be used as an imaging biomarker for heart failure.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.