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Abstract #3256

Quantitative Inversion Time Prescription for Late Gadolinium Enhancement Using T1-based Synthetic Inversion Recovery Imaging – Eliminating the Subjective Estimation of Inversion Time

Akos Varga-Szemes1, Rob J van der Geest2, Carlo N De Cecco1, Taylor M Duguay1, U. Joseph Schoepf1, and Pal Suranyi1

1Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States, 2Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Conventional Look-Locker (LL)-based inversion time (TI) estimation prior to late gadolinium enhancement (LGE) imaging has multiple limitations, including: the long breath-hold, the collected images are in different cardiac phases, and the subjective TI estimation. In this study we aimed to develop a quantitative T1 mapping-based synthetic inversion recovery (IRsynth) approach allowing for the quantitative determination of the optimal TI for LGE imaging. We showed in 40 patients that the IRsynth method provides better quality of myocardial signal nulling, retrospective TI selection, higher TI resolution, no need for further LL correction or TI adjustment, and less operator dependence.

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