Abstract #3256

Quantitative Inversion Time Prescription for Late Gadolinium Enhancement Using T1-based Synthetic Inversion Recovery Imaging – Eliminating the Subjective Estimation of Inversion Time

Akos Varga-Szemes¹, Rob J van der Geest², Carlo N De Cecco¹, Taylor M Duguay¹, U. Joseph Schoepf¹, and Pal Suranyi¹

¹Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States, ²Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Conventional Look-Locker (LL)-based inversion time (TI) estimation prior to late gadolinium enhancement (LGE) imaging has multiple limitations, including: the long breath-hold, the collected images are in different cardiac phases, and the subjective TI estimation. In this study we aimed to develop a quantitative T1 mapping-based synthetic inversion recovery (IR_synth) approach allowing for the quantitative determination of the optimal TI for LGE imaging. We showed in 40 patients that the IR_synth method provides better quality of myocardial signal nulling, retrospective TI selection, higher TI resolution, no need for further LL correction or TI adjustment, and less operator dependence.

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