Abstract #3270

Dynamic PET/MR Imaging of Glucose Utilization and Contractile Function Under Hypoxic Stress

Gregory Barton¹, Kara Goss², Niti Aggarwal³, Marlowe Eldridge¹, and Alan McMillan⁴

¹Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, ³Departments of Medicine & Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States

The purpose of this study was to establish a methodology that could be used to study the dynamic relationship between cardiac contractile function and metabolism in a serial rest-stress model using dynamic cardiac PET/MR. To assess dynamic changes in cardiac glucose metabolism we evaluated the use of a continuous infusion of ¹⁸F-FDG. We found that increases in cardiac contractility were coupled with an increase in glucose utilization in the myocardium under hypoxic stress conditions. These results demonstrate the feasibility of performing simultaneous measures of contractile function and metabolism in the heart.

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