Abstract #3274

Improving Shear Wave Signal-to-Noise Ratio in 3D High Frequency Cardiac Magnetic Resonance Elastography with Subjects in Prone Position

Shivaram Poigai Arunachalam¹, Arvin Arani¹, Ian Chang², Yi Sui¹, Phillip Rossman¹, Kevin Glaser¹, Joshua Trzasko¹, Kiaran McGee¹, Armando Manduca³, Richard Ehman¹, and Philip Araoz¹

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States, ³Biomedical Engineering and Physiology, Mayo Clinic, Rochester, MN, United States

Myocardial stiffness is a novel biomarker for diagnosing a variety of cardiac diseases. Our recent work demonstrated the feasibility of measuring in-vivo myocardial stiffness using 3D high frequency cardiac MR elastography (MRE) in normal volunteers using octahedral signal-to-noise ratio (OSS-SNR) as a shear wave quality metric. The purpose of this work is to determine whether scanning subjects in prone position can improve the OSS-SNR compared to supine position. 47 healthy volunteers were enrolled and OSS-SNR in prone position (mean: 1.98) was significantly higher (p < 0.01) than the OSS-SNR in supine position (mean: 1.52) with comparable mean stiffness.

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