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Abstract #3274

Improving Shear Wave Signal-to-Noise Ratio in 3D High Frequency Cardiac Magnetic Resonance Elastography with Subjects in Prone Position

Shivaram Poigai Arunachalam1, Arvin Arani1, Ian Chang2, Yi Sui1, Phillip Rossman1, Kevin Glaser1, Joshua Trzasko1, Kiaran McGee1, Armando Manduca3, Richard Ehman1, and Philip Araoz1

1Radiology, Mayo Clinic, Rochester, MN, United States, 2Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States, 3Biomedical Engineering and Physiology, Mayo Clinic, Rochester, MN, United States

Myocardial stiffness is a novel biomarker for diagnosing a variety of cardiac diseases. Our recent work demonstrated the feasibility of measuring in-vivo myocardial stiffness using 3D high frequency cardiac MR elastography (MRE) in normal volunteers using octahedral signal-to-noise ratio (OSS-SNR) as a shear wave quality metric. The purpose of this work is to determine whether scanning subjects in prone position can improve the OSS-SNR compared to supine position. 47 healthy volunteers were enrolled and OSS-SNR in prone position (mean: 1.98) was significantly higher (p < 0.01) than the OSS-SNR in supine position (mean: 1.52) with comparable mean stiffness.

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