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Abstract #3281

Vascular Access Mapping with Ferumoxytol MRA for TAVR Planning in Patients with Renal Impairment: A Step Closer Towards Patient-Specific Care

Kim-Lien Nguyen1,2, Takegawa Yoshida1,3, Adam N Plotnick1,3, John M Moriarty1,3, Peng Hu1,3, and J. Paul Finn1,3

1Diagnostic Cardiovascular Imaging Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 2Division of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 3Department of Radiological Sciences, David Geffen School of Medicine at UCLA

Transcatheter aortic valve replacement (TAVR) has transformed the treatment of critical aortic stenosis, particularly for those patients whose surgical operative risks are high. However, pre-TAVR vascular mapping with CT requires 40-120 mls of iodinated contrast, which in older patients with renal impairment increases the risk of acute renal injury that portends poor prognosis. We demonstrated that ferumoxytol MRA can provide reliable vascular mapping in patients with renal impairment undergoing TAVR evaluation, without exposure to iodinated or gadolinium contrast agents.

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