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Abstract #3287

Reproducibilty of Multiparametric Assessment of Chronic Kidney Disease

Charlotte Elizabeth Buchanan1, Huda Mahmoud2, Eleanor F Cox1, Benjamin Prestwich1, Nicholas M Selby2, Maarten W Taal2, and Susan T Francis1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Centre for Kidney Research and Innovation, University of Nottingham, Nottingham, United Kingdom

Chronic kidney disease (CKD) is a heterogeneous disease, with previous studies showing conflicting changes in MR parameters. Here, we use multi-parametric MRI of DWI, T1 and T2* mapping and ASL to assess haemodynamic and structural changes in Stage 3 and 4 CKD patients and examine the reproducibility of these measures. A significant reduction in renal cortex ADC and perfusion was found between CKD patients and healthy volunteers. In contrast, renal cortex and medulla T1 values increased in CKD, with a reduction in corticomedullary differentiation. MR measures in CKD patients were found to be highly reproducible between scan sessions.

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