Abstract #3287

Reproducibilty of Multiparametric Assessment of Chronic Kidney Disease

Charlotte Elizabeth Buchanan¹, Huda Mahmoud², Eleanor F Cox¹, Benjamin Prestwich¹, Nicholas M Selby², Maarten W Taal², and Susan T Francis¹

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Centre for Kidney Research and Innovation, University of Nottingham, Nottingham, United Kingdom

Chronic kidney disease (CKD) is a heterogeneous disease, with previous studies showing conflicting changes in MR parameters. Here, we use multi-parametric MRI of DWI, T₁ and T₂* mapping and ASL to assess haemodynamic and structural changes in Stage 3 and 4 CKD patients and examine the reproducibility of these measures. A significant reduction in renal cortex ADC and perfusion was found between CKD patients and healthy volunteers. In contrast, renal cortex and medulla T₁ values increased in CKD, with a reduction in corticomedullary differentiation. MR measures in CKD patients were found to be highly reproducible between scan sessions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.