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Abstract #3288

Multiparametric Assessment of Acute Kidney Injury

Charlotte Elizabeth Buchanan1, Huda Mahmoud2, Eleanor F Cox1, Benjamin Prestwich1, Maarten W Taal2, Nicholas M Selby2, and Susan T Francis1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Centre for Kidney Research and Innovation, University of Nottingham, Nottingham, United Kingdom

Acute Kidney Injury (AKI) is a sudden reduction in kidney function, with causes and degree of renal recovery varying widely between individuals. MRI provides a method to assess changes associated with AKI. Here, we use multi-parametric MRI to monitor renal changes in AKI at time of injury and recovery. At peak AKI an increase was seen in renal volumes and T2* values while cortical ADC and perfusion was lower during the AKI phase. T1 maps showed an increase at time of AKI with a reduction in corticomedullary differentiation. At 3 months post AKI, T1 remained higher than HVs.

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